You can watch the pilot here.
Voice actors include Paul Giamatti, David Hyde Pierce, Molly Shannon, and actor/comedian/comics nerd Patton Oswalt. (Oswalt's last stand-up album, Feelin' Kinda Patton, was the funniest and most wrong since Bill Hicks.)
"In this hilarious send-up of Lovecraftian horror and steampunk adventure, President Abraham Lincoln's top spy is a bodyless head known only as Screw-On Head.
When arch-fiend Emperor Zombie steals an artifact that will enable him to threaten all life on Earth, the task of stopping him is assigned to Screw-on Head. Fortunately, Screw-On Head is not alone on this perilous quest. He is aided by his multitalented manservant, Mr. Groin, and by his talking canine
cohort, Mr. Dog."